Snake Venom Proteases

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  • Echis Carinatus Prothrombin Activator (Echarin)

    ECVVII-2011
    Price: $1,730.00/1 mg, $191.00/100 µg
    Safety Data Sheet
    Size 1 mg, 100 µg
    Formulation 50% glycerol/water (v/v)
    Storage -20°C
    Shelf Life 12 months
    Source Vipera Echis Carinatus
    Molecular Weight 56,000, single chain
    Class metalendo-peptidase
    Inhibitors EDTA, DTT, o-phenanthroline
    Application Cleavage of Arg323-Ile324 bond in prothrombin to form meizothrombin
    Use start at a 1:500 (enzyme:substrate) mass ratio for activation  (e.g. 2 ug enzyme per 1 mg of material activated).  Exact ratios and conditions must be determined in your lab.

  • RVV-V Activator

    RVVV-2000
    Price: $540.00/1 mg, $60.00/100 µg
    Sample Data Sheet  |  Safety Data Sheet
    Size 1 mg, 100 µg
    Formulation 50% glycerol/water (v/v)
    Storage -20°C
    Shelf Life 12 months
    Source Vipera Russelli Russelli
    Molecular Weight 27,200 - single chain glycoprotein
    Class serine protease
    Inhibitors DFP
    Application converts single chain factor V to an active two chain form
    Use start at a 1:500 (enzyme:substrate) mass ratio for activation  (e.g. 2 ug enzyme per 1 mg of material activated).  Exact ratios and conditions must be determined in your lab.

  • RVV-X Activator

    RVVX-2010
    Price: $540.00/1 mg, $60.00/100 µg
    Safety Data Sheet
    Size 1 mg, 100 µg
    Formulation 50% glycerol/water (v/v)
    Storage -20°C
    Shelf Life 12 months
    Source Vipera Russelli Russelli
    Molecular Weight 79,000 glycoprotein 2 disulfide linked subunits (Mr = 67kD, 26kD)
    Class Zn+2 dependant endopeptidase
    Inhibitors EDTA, o-phenanthroline
    Application Conversion of factor X to Xa, factor IX to IXaα
    Use start at a 1:500 (enzyme:substrate) mass ratio for activation  (e.g. 2 ug enzyme per 1 mg of material activated).  Exact ratios and conditions must be determined in your lab.

No overview available.

Sample gel image
Gel Novex 4-12% Bis-Tris
Load RVV-V and RVV-X, 1 µg per lane
Buffer MOPS
Standard SeeBluePlus 2; Myosin (191 kDa), Phosphorylase B (97 kDa), BSA (64 kDa), Glutamic Dehydrogenase (51 kDa), Alcohol Dehydrogenase (39 kDa), Carbonic Anhydrase (28 kDa), Myoglobin Red (19 kDa), Lysozyme (14 kDa)

No properties available.

  1. Kisiel, W., et.al., Biochen., 15, 4901-4905 (1976).
  2. Kisiel, W. and Canfield, R., Meth.Enzymol., 80, 275-285 (1980).
  3. Kane, W. and Majerus, P.J., J.Biol.Chem., 256, 1002-1007 (1987).
  4. Morita, T. and Iwanaga, S., Meth.Enzymol., 80, 303-311 (1980).
  1. Dasgupta, S., et al., Blood. 2009 113: 1332-1339. (RVVX in thrombin generation)

This publication list is not all encompassing, and is only meant to provide limited examples of how Prolytix products are used. We encourage you to search the literature for other examples pertinent to your experimentation, and to contact us with any technical questions.

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