There is a major reproducibility issue in clinical research, and reagents that lack rigorous quality control are partly to blame. Estimates of irreproducibility range from 75% to 90%,1 with past approximations of the cost weighing in at $28B per year in the U.S. alone.2 Of this staggering amount, 36% was caused by substandard “biological reagents …
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When doing Host Cell Protein analysis by mass spectrometry, we often fail to appreciate the “why” of the HCPs that show up in our protein lists – why did these HCPs co-purify with the Product, and why are they important? Clusterin shows up in almost every HCP project we work on. Why?
