The Role of HRMS In Vaccine Process Development

Vaccine development has come a long way from the days of the first smallpox vaccines, which consisted of nothing more than pus harvested from bovine sores. Technological advancements in the field of vaccine development have made it possible to target a broader range of diseases in wider populations than has been possible before, but they have also created the need for more precise and sophisticated purification processes — the detection and elimination of host cell proteins (HCPs), for example, which in some cases can create safety hazards or reduce vaccine efficacy. In this blog, Dr. Kevin Van Cott discusses how purity analysis using high-resolution mass spectrometry (HRMS) can shorten vaccine development timelines and improve vaccine purity, efficacy, and safety.

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